Target brand erythromycin

Erythromycin dosing information

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. QT prolongation and ventricular arrhythmia including torsades de pointes. Do not eat grapefruit or drink grapefruit juice while you use erythromycin. Although the optimal dose and duration of therapy have not been established, the suggested treatment is 500 mg of erythromycin by mouth four times a day on an empty stomach for at least 7 days. For women who cannot tolerate this regimen, a decreased dose of one erythromycin 500 mg tablet orally every 12 hours or 250 mg by mouth four times a day should be used for at least 14 days.

Erythromycin uses

CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. Erythromycin acts by inhibition of protein synthesis by binding 50 S ribosomal sub-units of susceptible organisms. It does not affect nucleic acid synthesis. Antagonism has been demonstrated in vitro between erythromycin and clindamycin, lincomycin, and chloramphenicol.

What is acute kidney injury?

Erythromycin has been associated with QT prolongation and ventricular arrhythmias, including ventricular tachycardia and torsades de pointes. Cough, shortness of breath, and pulmonary infiltrates. Safety and effectiveness of this product in pediatric patients have not been established. Clinical and Laboratory Standards Institute CLSI.

What should i avoid while taking erythromycin

Ointment, solution: Apply to affected area twice daily morning and evening; drying and peeling may be controlled by reducing the frequency of application. Erythromycin is to be used only by the patient for whom it is prescribed. Do not share it with other people. Offergeld R, Reinecker C, Gumz E, et al. Mitogenic activity of high molecular polysaccharide fractions isolated from the cuppressaceae Thuja occidentalis L. enhanced cytokine-production by thyapolysaccharide, g-fraction TPSg.



Erythromycinethylsuccinat PH: Ph Eur

The effects of Erythromycin and Sulfisoxazole on labor and delivery are unknown. If you are giving this medication to yourself at home, learn all preparation and usage instructions from your professional. Before using, check this product visually for particles or discoloration. If either is present, not use the liquid. Learn how to store and discard medical supplies safely. Oie S. Gambertoglio JG, Fleckenstein L: Comparison of the disposition of total and unbound sulfisoxazole after single and multiple dosing. J Pharmacokinet Biopharm 1982; 10: 157 - 172. Erythromycin is contraindicated in patients with known hypersensitivity to this antibiotic. Angioedema, arteritis, and vasculitis. Erythromycin stearate PH: Ph. Eur. Adverse events were not observed in animal reproduction studies. Erythromycin has been shown to cross the placenta following oral dosing. Refer to the Erythromycin Systemic monograph for details. The amount of erythromycin available systemically following topical application is considered to be very low Akhavan, 2003. Systemic absorption would be required in order for erythromycin to cross the placenta and reach the fetus. Topical erythromycin may be used for the treatment of acne in pregnancy Dréno, 2013; Eichenfield, 2013; Gollnick, 2003. Erythromycin has the molecular weight of 733. Pregnant women receiving erythromycin estolate may be more prone to hepatotoxicity. In one study of women receiving erythromycin estolate between the 22nd and 32nd week of pregnancy, 10% showed abnormal levels of SGOT. Serious reactions, including anaphylaxis, have occurred. If the standardized procedure of disc susceptibility is used, a 15 mcg erythromycin disc should give a zone diameter of at least 18 mm when tested against an erythromycin-susceptible bacterial strain, and a 250-300 mcg sulfisoxazole disc should give a zone diameter of at least 17 mm when tested against a sulfisoxazole-susceptible bacterial strain. Use drug cautiously. Hepatic function impairment, with or without jaundice, has occurred. Cholestatic hepatitis has occurred. Monitor patient for signs and symptoms of liver dysfunction eg, dark urine, fatigue, flu-like symptoms, persistent nausea, right-upper quadrant abdominal pain, yellowing of skin or eyes. Discontinue therapy immediately if noted or suspected.



Does erythromycin interact with other medications

Some medical conditions may interact with erythromycin gel. Pre-op Day 2: Minimum residue or clear liquid diet. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Caution is advised when this drug is used in infants. Though very unlikely to occur, there have been rare reports of a problem called IHPS infantile hypertrophic in infants receiving this medication. Contact your child's doctor right away if the child has persistent or increased irritability. There have been reports of increased anticoagulant effects when erythromycin and oral anticoagulants were used concomitantly. Increased anticoagulation effects due to interactions of erythromycin with various oral anticoagulants may be more pronounced in the elderly. If you miss a dose of Maxitrol drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. The patient should be monitored with blood counts and appropriate blood chemistries, including electrolytes. Keep tube tightly closed. Patients using Erythromycin Topical Gel USP, 2% should receive the following information and instructions: 1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes, nose, mouth, and all mucous membranes. 2. This medication should not be used for any disorder other than that for which it was prescribed. 3. Patients should not use any other topical acne medication unless otherwise directed by their physician. 4. Patients should report to their physician any signs of local adverse reactions. Do not take additional laxatives or stool softeners with bisacodyl unless directed by your doctor. For topical use only; not for ophthalmic use. Concomitant topical acne therapy should be used with caution because a possible cumulative irritancy effect may occur, especially with the use of peeling, desquamating or abrasive agents. Areas to be treated should be cleansed prior to application. The duration of therapy depends on the response of the patient. Maximum response may not occur for up to 12 weeks. Several published reviews have indicated that ototoxicity was associated with erythromycin dosages greater than 4 grams per day, preexisting liver or kidney disease, and advanced age. Recovery generally occurred within two weeks. Age, weight, and severity of the infection are important factors in determining the proper dosage. combivent



Monitor patient's response to therapy

Patients with a history of hypersensitivity or serious toxic reaction to other aminoglycosides may have a cross-sensitivity to neomycin. Neomycin Sulfate oral preparations are contraindicated in patients with inflammatory or ulcerative gastrointestinal disease because of the potential for enhanced gastrointestinal absorption of neomycin. To clear up your infection completely, use Maxitrol drops for the full course of treatment. Keep using it even if you feel better in a few days. There have been post-marketing reports of drug interactions when erythromycin is co-administered with cisapride, resulting in QT prolongation, cardiac arrhythmias, ventricular tachycardia, ventricular fibrillation, and torsades de pointes most likely due to inhibition of hepatic metabolism of cisapride by erythromycin. Fatalities have been reported. Pre-op Day 3: Minimum residue or clear liquid diet. Onset of pseudomembranous colitis symptoms has been reported during or after antibacterial therapy. The following are examples of some clinically significant CYP3A based drug interactions. Interactions with other drugs metabolized by the CYP3A isoform are also possible. Damage from some medicines, poisons, or infections. Most people don't have any kidney problems from taking medicines. But people who have serious, long-term health problems are more likely than other people to have a kidney problem from medicines. Ask your health care provider any questions you may have about how to use Maxitrol drops. Topical Apply 1 to 4 times daily to affected area. For topical use only. Keep away from mouth, nose, eyes, and other mucus membranes. After the diagnosis of pseudomembranous colitis has been established, therapeutic measures should be initiated. Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone. In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation and treatment with an antibacterial drug clinically effective against C. difficilecolitis. Prolonged use of antibiotics may result in bacterial or fungal overgrowth of nonsusceptible microorganisms. Guelon D, Bedock B, Chartier C, Haberer JP "QT prolongation and recurrent "torsades de pointes" during erythromycin lactobionate infusion. generic form of lamisil side effects lamisil



Highlights for erythromycin

No. 25, NCCLS Villanova, PA, December 1993. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Additional manifestations of neurotoxicity may include numbness, skin tingling, muscle twitching and convulsions. May decrease Cl of methylprednisolone. For the best effect, use this antibiotic at evenly spaced times. To help you remember, use this medication at the same times every day. STEARATE Film-coated Tablets erythromycin stearate tablets, USP are supplied in the following strengths and packages. Erythromycin ethylsuccinate tablets may be administered without regard to meals. To avoid unpleasant taste, the 400 mg tablets should not be chewed. In the presence of normal hepatic function, erythromycin is concentrated in the liver and is excreted in the bile; the effect of hepatic dysfunction on biliary excretion of erythromycin is not known. After oral administration, less than 5% of the administered dose can be recovered in the active form in the urine. This is mixed in the correct fluid and given slowly into a vein as directed by your doctor, usually every 6 hours. may be given continuously or slowly over 20 to 60 minutes as separate doses at evenly spaced intervals. Dosage and length of treatment are based on your medical condition and response to therapy. You should use this injectable medication only until you are able to take an antibiotic by or until your treatment is finished. Chemically, erythromycin is C 37H 67NO 13. For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same times every day. Patients using Erythromycin Topical Solution USP, 2% should receive the following information and instructions: 1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes, nose, mouth, and all mucous membranes. 2. This medication should not be used for any disorder other than that for which it was prescribed. 3. Patients should not use any other topical acne medication unless otherwise directed by their physician. 4. Patients should report to their physician any signs of local adverse reactions. Two year oral studies conducted in rats with did not provide evidence of tumorigenicity. Mutagenicity studies have not been conducted. No evidence of impaired fertility that appeared related to erythromycin was reported in animal studies. If your symptoms do not improve within a few days, or if they become worse, check with your doctor.



Side effects of erythromycin

Orally administered erythromycin base and its salts are readily absorbed. Because of interindividual variation in absorption, some patients do not achieve optimal serum concentrations. Erythromycin ointment may be used around the eye or in the eye. To use erythromycin ointment in the eye, first, wash your hands. Using your index finger, pull the lower eyelid away from your eye to form a pouch. Squeeze a thin strip of ointment into the pouch. After using erythromycin ointment, gently close your eyes for 1 to 2 minutes. Wash your hands to remove any medicine that may be on them. Wipe the applicator tip with a clean, dry tissue. What other drugs will affect erythromycin and sulfisoxazole Pediazole? For diarrhea in malnourished or zinc-deficient children: 10-40 mg elemental zinc daily. Administer erythromycin base or stearate on an empty stomach. For administration by continuous or intermittent IV infusion only. Not for intradermal, subcutaneous, IM, IV bolus, or intra-arterial administration. It works by killing sensitive bacteria. In vitro sulfonamides susceptibility tests are not always reliable because media containing excessive amounts of thymidine are capable of reversing the inhibitory effect of sulfonamides, which may result in false resistant reports. The tests must be carefully coordinated with bacteriological and clinical responses. When the patient is already taking sulfonamides, follow-up cultures should have aminobenzoic acid added to the isolation media but not to subsequent susceptibility test media. Orally administered erythromycin ethylsuccinate tablets are readily and reliably absorbed. Comparable serum levels of erythromycin are achieved in the fasting state and nonfasting states. Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. What happens if I overdose? When Neomycin Sulfate tablets are prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment and 2 increase the likelihood that bacteria will develop resistance and will not be treatable by Neomycin Sulfate tablets or other antibacterial drugs in the future. okfu.info azithromycin



Before taking erythromycin

Aktipak may bleach hair or colored fabric. Zimmer M. Specific conservative treatment of acute sinusitis in the ENT practice. To apply eye ointments, tilt your head back, look up, and gently pull down the lower eyelid to make a pouch. Place about a half-inch 1 centimeter strip of ointment into the pouch as directed by your doctor. Gently close the eye and roll the eyeball in all directions to spread the medication. Try not to blink and do not rub the eye. Repeat these steps for your other eye if so directed. Wipe the tip of the ointment tube with a clean tissue to remove extra medication before recapping it. Wait several minutes for your vision to clear before driving or operating machinery. For hypogeusia sense of taste is abnormal: 25-100 mg zinc. Inman WH, Rawson NS "Erythromycin estolate and jaundice. Ophthalmic 1-cm ribbon of ointment placed in each conjunctival sac at time of delivery. Advise patient to apply sparingly to affected areas morning and evening using fingers or applicator. Remind patient to wash hands before and after applying medication. Assess patient's response to therapy. Be prepared to reduce frequency of application if dryness and peeling occurs. Be prepared to discontinue therapy if more severe reactions eg, burning, allergic reaction, severe peeling, desquamation occur. Granberry MC, Gardner SF "Erythromycin monotherapy associated with torsade de pointes. The use of agents may be associated with the overgrowth of nonsusceptible organisms including fungi; in such a case, administration should be stopped and appropriate measures taken. ipratropium 10mg australia



General information about erythromycin

Nattel S, Ranger S, Talajic M, et al "Erythromycin-induced long QT syndrome: concordance with quinidine and underlying cellular electrophysiologic mechanism. Erythromycin Topical Gel USP, 2% is contraindicated in those individuals who have shown hypersensitivity to any of its components. Advise patient to notify health care provider if acne does not improve, if it worsens, or if application-site reactions occur. Treatment of superficial ocular infections caused by strains of susceptible organism; prophylaxis of neonatal conjunctivitis. STEARATE Film-coated tablets, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile. Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health acre professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. The amount of a single dose of sulfisoxazole that is either associated with symptoms of overdosage or is likely to be life-threatening has not been reported. Signs and symptoms of overdosage reported with sulfonamides include anorexia, colic, nausea, vomiting, dizziness, headache, drowsiness and unconsciousness. Pyrexia, hematuria and crystalluria may be noted. Blood dyscrasias and jaundice are potential late manifestations of overdosage. What conditions does Erythromycin treat? Elderly patients may be more susceptible to development of torsades de pointes arrhythmias than younger patients. Chewable forms of erythromycin should be crushed or chewed before being swallowed. The major route of resistance is modification of the 23S rNA in the 50S ribosomal subunit to insensitivity while efflux can also be significant.



List of erythromycin side effects

Instruct patient in proper use of ointment: wash hands before and after instilling ointment; tilt head backward or lie down and gaze upward; gently pull down lower lid to form a pouch and place prescribed amount of ointment with a sweeping motion inside the lower eyelid; close eyes for 1 to 2 min and roll the eyeball in all directions; remove excessive ointment around eye with tissue. Seek emergency medical attention if you think you have used too much of this medicine. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue. USP every 6 hours for 3 days, followed by 500 mg of erythromycin base orally every 12 hours, or 333 mg of erythromycin base orally every 8 hours for 7 days. If you notice a sudden change in bowel habits that lasts for 2 weeks or more, do not continue using bisacodyl. Instead, check with your doctor. Erythromycine propionate d' PH: Ph. Franç. Use tolterodine as directed by your doctor. Check the label on the medicine for exact dosing instructions. buy anafranil online in australia



How to use erythromycin

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Your pharmacist can provide more information about erythromycin and sulfisoxazole. Caution is advised when using tolterodine in CHILDREN; they may be more sensitive to its effects, especially an increased risk of urinary tract infection or behavior or attention problems. Easmon CS, Hastings MJ, Deeley J, Bloxham B, Rivers RP, Marwood R "The effect of intrapartum chemoprophylaxis on the vertical transmission of group B streptococci. Wash affected areas with soap and water. Rinse well and pat dry before applying the medicine. Tschida SJ, Guay DRP, Straka RJ, Hoey LL, Johanning R, Vancebryan K "QTc-interval prolongation associated with slow intravenous erythromycin lactobionate infusions in critically ill patients: a prospective evaluation and review of the literature. Erythromycin is excreted into human milk in small amounts. Erythromycin is considered compatible with breast-feeding by the American Academy of Pediatrics. Refer to adult dosing. elimite



F Protect from heat and flame

Inform your doctor if your condition does not improve or if it worsens. It may take up to 3 months of regular use before the full benefits of this medication take effect. There have been reports that erythromycin may aggravate the weakness of patients with myasthenia gravis. Quinn PA, Shewchuk AB, Shuber J, et al. "Eficacy of antibiotic therapy in preventing spontaneous pregnancy loss among couples colonized with genital mycoplasms. Erythromycin interferes with the fluorometric determination of urinary catecholamines. Pseudomembranous colitis has been rarely reported in association with erythromycin therapy. Wide variation in levels may result following identical doses of a sulfonamide. Blood levels should be measured in patients receiving these drugs for serious infections. Erythromycin often in 5 to 30% of the cases causes gastrointestinal pain nausea, vomiting, gastric pain, abdominal cramps. High single doses are not suitable; children experience adverse reactions more frequently. There seem to be hepatotoxic reactions with all erythromycin preparations, but they are reversible after the discontinuation of the drug. The transaminases increase in about 10%; jaundice appears in only 1 of 1000 treated subjects. Ototoxic effects are also infrequent and reversible hearing loss, ringing in the ear. Other rare side-effects include skin reactions, nephritis, fever and eosinophilia, pancreatitis, colitis and myasthenia. Pre-op Day 1: Clear liquid diet. Supplemental IV fluids as needed. Erythromycin may interact with these medicines and could cause dangerous or life-threatening heart rhythm disorders. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness. Protect tablets from exposure to light and moisture. See package insert for lovastatin. Keep using it even if you feel better in a few days. The total daily dose of erythromycin ethylsuccinate and sulfisoxazole acetyl for oral suspension should be administered in equally divided doses three or four times a day for 10 days. Erythromycin ethylsuccinate and sulfisoxazole acetyl for oral suspension may be administered without regard to meals. Red No. 40, magnesium stearate, polacrilin potassium and sodium citrate.



Common side effects of erythromycin

The following in vitro data are available, but their clinical significance is unknown. This interaction should be kept in mind when Pediazole erythromycin and sulfisoxazole is given to patients already on anticoagulant therapy, and the time should be reassessed. You can help yourself heal by taking your medicines as your doctor tells you to. You also may need to follow a special diet to keep your kidneys from working too hard. Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label. Erythromycin acts by inhibition of by binding 50 S ribosomal subunits of susceptible organisms. It does not affect synthesis. Antagonism has been demonstrated between erythromycin and clindamycin, lincomycin, and chloramphenicol. Wash your hands before and after using this medicine. doxazosin can i order pharmacy



How should I use erythromycin topical?

If you need to have any type of surgery, tell the surgeon ahead of time that you are using erythromycin and sulfisoxazole. You may need to stop using the medicine for a short time. It has been proposed that sulfisoxazole competes with thiopental for binding. In one study involving 48 patients, sulfisoxazole resulted in a decrease in the amount of thiopental required for and in a shortening of the awakening time. It is not known whether oral doses of sulfisoxazole have a similar effect. Until more is known about this interaction, physicians should be aware that patients receiving sulfisoxazole might require less thiopental for anesthesia. Continued How is acute kidney injury diagnosed? The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice. Treatment of acne vulgaris. The combination of erythromycin and sulfisoxazole is used to ear infections in children. Post-marketing reports indicate that co-administration of erythromycin with ergotamine or dihydroergotamine has been associated with acute ergot toxicity characterized by vasospasm and ischemia of the extremities and other tissues including the central nervous system. Erythromycin is a white or slightly yellow crystalline powder that is slightly soluble in water, freely soluble in alcohols, acetone, chloroform, acetonitrile, ethyl acetate, and moderately soluble in ether, ethylene dichloride and amyl acetate. After absorption, erythromycin diffuses readily into most body fluids. Erythromycin lactobionate PH: Ph. Eur. Acute kidney injury is most often diagnosed during a hospital stay for another cause. If you are already in the hospital, tests done for other problems may find your kidney problem. Warn patient that diarrhea containing blood or pus may be a sign of a serious disorder and to seek medical care if noted and not treat at home, even if diarrhea occurs after stopping the antibiotic. omifin



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Erythromycini estolas PH: Ph Eur


Erythromycin brand names

What should I discuss with my healthcare provider before taking erythromycin and sulfisoxazole Pediazole? The frequency of renal complications, commonly associated with some sulfonamides, is lower in patients receiving the more soluble sulfonamides such as sulfisoxazole. IV 250 mg twice daily given continuously. Primary syphilis caused by Treponema pallidum. Erythromycin oral forms only is an alternative choice of treatment for primary syphilis in patients allergic to the penicillins. In treatment of primary syphilis, spinal fluid should be examined before treatment and as part of the follow-up after therapy. target brand cefadroxil

What is erythromycin

Erythromycin is excreted in human milk. Caution should be exercised when erythromycin is administered to a nursing woman. Listeriosis caused by Listeria monocytogenes. Neomycin is quickly and almost totally absorbed from body surfaces except the urinary bladder after local irrigation and when applied topically in association with surgical procedures. Delayed-onset irreversible deafness, renal failure and death due to neuromuscular blockade regardless of the status of renal function have been reported following irrigation of both small and large surgical fields with minute quantities of neomycin.

It is for external use only

The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the ointment tube with the tip pointing toward this pocket. Look up and away from the tip. Pregnancy: Effects. Pregnancy Category C. At dosages 7 times the human daily dose, sulfisoxazole was not teratogenic in either rats or rabbits. However, in two other teratogenicity studies, cleft palates developed in both rats and mice after administration of 5 to 9 times the human therapeutic dose of sulfisoxazole.

Prescribing information for erythromycin

It is not known whether erythromycin passes into breast milk when given as an eye ointment. It is unlikely to harm a nursing infant. Consult your doctor before breast-feeding. Erythromycin crosses the placenta in small amounts. In one study of 11 patients who had detectable erythromycin levels in the serum, 4 infants did not have detectable cord concentrations. The cord concentrations in the remaining 7 infants generally ranged from 1% to 6% of that found in maternal serum. Tolterodine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use tolterodine with caution.

Exacerbation of symptoms of myasthenia gravis and new onset of symptoms of myasthenic syndrome has been reported in patients receiving erythromycin therapy. Erythromycin significantly alters the metabolism of terfenadine when taken concomitantly. Rare cases of serious cardiovascular adverse events, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias, have been observed. Leukopenia, agranulocytosis, aplastic anemia, thrombocytopenia, purpura, hemolytic anemia, anemia, eosinophilia, clotting disorders including hypopro-thrombinemia and hypofibrinogenemia, sulfhemoglobinemia, and methemoglobinemia. lamictal

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